In this article, I will start with a review of some of the extensive medical literature related to cannabinoids and pain as well as skin conditions including Psoriasis, Eczema and acne. My goal here is to produce a well cited resource for my readers.  

After the informational section you will find my review of the best CBD pain creams on the market. These products were selected after extensive research into dozens of the top CBD oil manufacturers, full reviews of which you can find on my site.  

In addition to brand trustworthiness and overall quality, I looked at each product and recommended only those that I found with a very high attention paid to using the best ingredients overall with priority given to all-natural ingredients and those creams that contained additional ingredients with known natural properties to support reduction in pain and inflammation.  

Consider bookmarking this resource or passing it along to your friends. I will be keeping this page updated with new CBD creams that make the cut as they are released so check back! 

CBD Cream for Pain and Inflammation 

One of the more developed areas of research concerning the topical application of CBD has to do with how it can reduce pain and inflammation. These two symptoms are related, so I have decided to cover them together.  

There are two basic kinds of pain 

“Nociceptive pain” is when the nerve fibers are acted on by one of three mechanisms: chemical, inflammation or mechanical.  

When you stub your toe, this is a form of nociceptive pain with a mechanical trigger. If your toe swells up and becomes inflamed, the pain is still nociceptive, only now the cause is the inflammation that is acting on the nerves.  

Neuropathic pain” is actually generated from the nervous system itself, and by definition, it does not have an external cause, rather, it is a malfunction of the central nervous system. It is often described as a shooting or burning pain, sometimes accompanied with tingling “pins and needles” or numbness.  

This kind of pain can be caused by many different factors or medical conditions, including (but not limited to): 

  • Multiple Sclerosis 
  • Arthritis  
  • Shingles 
  • Facial neuralgia 
  • HIV or AIDS 
  • Diabetes 
  • Fibromyalgia 
  • Chemotherapy 
  • Spinal surgery 
  • Spinal cord compression and/or arthritis in the spinal column 
  • Amputation 


Although the mechanisms for each kind of pain are clearly different, cannabinoids, in combination with the body’s natural endocannabinoid system, have been the focus of a significant amount of scientific research with evidence that points to CBD as effective for both nociceptive and neuropathic pain, as well as inflammation more specifically.  

By the way, if you are looking for a more in depth article that gets into the nitty gritty of the science behind CBD and pain, check out this academic article published for the British Journal of Anaesthesia 


Finding the Best CBD Pain Creams For Sale

Whether you are looking for CBD cream for back pain or CBD foot cream, the quality indicators are pretty much the same. Although clever marketing campaigns sometimes name certain conditions, the fact is that it is the additional ingredients in a formula that may make a specific CBD better for one or more conditions.  

For example, if you are looking for a CBD cream for psoriasis, additional ingredients that are known to help with moisturizing the skin or soothing the itchiness of this condition, in addition to the hemp oil present, would be extra helpful.  

On the other hand, CBD pain cream for sore muscles and joints from sports injuries or arthritis may benefit from ingredients such as menthol or arnica. 

This review is for the best CBD creams for pain relief, but if you want to check on my top pick for a specific condition, here are some other links to check out to find the best CBD cream for: 

  • Psoriasis 
  • Eczema 
  • Acne 
  • Sciatica 
  • Arthritis 
  • Fibromyalgia


Don’t worry! If it sounds too complicated to follow, I have done the research and can guide you through the process of finding the exact right CBD cream for your individual needs.  

All of the products featured below are from companies that I have researched for quality, most of which you can search on my site to find a complete, point by point honest review.  


Best CBD Creams for Pain 

Whether you are looking for an opioid free topical to help with pain from sciatica, arthritis, or fibromyalgia, CBD pain relief cream may be worth trying. Typically, these creams have a higher concentration of CBD than other topicals on the market as well as other ingredients to support pain relief.  

These picks all come from reputable manufacturers and include a top-notch list of ingredients to support the pain and inflammation reducing properties of the best CBD salves for pain.  


Cannabidiol Life – Deep Soothing Balm 

Cannabidiol Life is based out of Denver, CO and offers a full spectrum hemp oil that they use in their products, including this Deep Soothing CBD Balm. If you want to see the latest third-party testing on this product, it is available when you click the product link provided for your convenience.  

Full spectrum oils have a range of cannabinoids from hemp, as opposed to products developed with an isolated form of CBD. There is research to support the fact that full spectrum hemp oil may have better overall benefits as the compounds found in the hemp plant are thought to enhance each other.  

This formula is specially developed to target aches and pains and contains all-natural ingredients to support pain relief including arnica, peppermint, st. john wart, camphor and clove essential oils.  


Strength: 275mg/oz. full spectrum CBD 

Scent: Natural Hemp or Lemongrass 



  • All-natural ingredients carefully selected for optimal pain relief 
  • Additional ingredients such as shea butter, organic beeswax and organic cocoa butter to support a deep moisturizing experience 
  • Based on a full spectrum hemp oil 
  • Made in the USA 
  • Comes in a natural scent for those sensitive to fragrances 
  • Trusted CBD oil company with a strong reputation 



  • Not as concentrated as some other formulas 
  • A little pricey per mg of CBD, but the top-shelf ingredients make it worth while  


Receptra Naturals – Targeted Topical 

A family owned and operated company out of Denver, CO, Receptra Naturals is one of those CBD companies that really stands out for quality manufacturing, transparent lab testing, and excellent value in their products.  

They are geared towards the use of hemp oil products as natural performance enhancers, and their target audience tends to be athletes. Working in partnership with the MMA, this small company is bringing the benefits of CBD oil to those with very active lifestyles looking for relief from sore muscles and joints.  

Their Targeted Topical product is potent, with a whopping 320mg of CBD in every ounce. To say a little goes a long way is an understatement! It is also a full spectrum oil AND it is derived from only the flowers of the organic, domestic industrial hemp they source from family owned Colorado farms.  

Good stuff! 

Strength: 320mg/oz. full spectrum CBD 

Scent:  Natural Jasmine and Ylang Ylang 



  • Extremely reasonable price per mg of CBD 
  • Highly potent formula for a fast acting topical to target sore muscles and joints 
  • All-natural ingredients with some excellent high-end additions including coconut, shea, shorea and mango butter for moisture and protection along with Arnica and camphor to support pain relief 
  • Sourced from organic Colorado hemp and manufactured in the USA 
  • Flower only, ethanol based, full spectrum extraction 
  • Delightful fresh scent that is not overpowering 



  • May be too concentrated for first time users  


Highland Pharms – Therapy+ CBD Cream 

One of the most established and oldest CBD companies in the industry, Highland Pharms has been around since the start of the CBD oil industry in 2015. They use pharmaceutical grade, high CBD strains of hemp that is organic and grown in California.  

When you look at lab reports as much as I do, you start to see a big difference in terms of the range of cannabinoids in the final product. If you look over their third-party testing which you can find on their site, you will see their full spectrum oil is very robust.  

This CBD pain relief cream includes a strong list of ingredients including eucalyptus, which is both anti-inflammatory as well as anti-bacterial, and Rosemary, an anti-oxidant and neural protectant. This is an excellent choice to try if you want to see if a CBD rub will help with your neuropathic pain from conditions such as fibromyalgia or sciatica.  

Strength: 50mg/oz. full spectrum CBD 

Scent: Light hint of rosemary


  • Rich full spectrum CBD base made from organic and domestically sourced pharmaceutical grade hemp 
  • Excellent supporting ingredients including mango butter, apricot oil, and aloe Vera 
  • Made in the USA 
  • Transparent third-party testing 
  • Paraben free formula 



  • Pricey per mg of CBD, but honestly some of the richest full spectrum CBD oil on the market 
  • Does contain Optiphen, a paraben free preservative 
  • Low strength may not be suitable for all users 


CBDISTILLERY –  Topical CBD Salve 

One of the most potent CBD salves for pain on the market, this is a great product to try if you are an experienced user of CBD products, or you are going for high doses of topical CBD.  

It is based on a full spectrum extraction and includes a whopping 500mg of CBD in each ounce. It comes in a tiny bottle…so just start with a very small amount of this salve and give it at least 15 minutes before applying more.  

CBDistillery is one of my top recommended brands for a reason – they offer great prices for a really well made and consistent product.  

Strength: 500mg/oz. full spectrum CBD 



  • Extremely potent topical  
  • Excellent value when calculated at a per mb CBD rate 
  • Pain relief supporting ingredients including camphor, arnica and eucalyptus 
  • All-natural ingredients 
  • Full spectrum oil for the supporting role provided by additional cannabinoids 
  • USA based business run by Colorado natives 
  • Third party testing available on their website 



  • Too potent for some users, particularly those new to CBD topicals 
  • Some customers find the hempy scent to be too strong 


Ananda Hemp – Spectrum Salve 125 

 A few CBD oil manufacturers are setting their product apart by using specially bred strains of industrial hemp that are high in CBD and using only the most potent part of the plant, the flower. Ananda Hemp is one of these manufacturers.  

Working with the Kentucky Department of Agriculture, farmer Brian Furnish isn’t just third-party grower, he is an executive at the company. Importing the best seeds from around the world, Ananda Hemp has full seed to bottle control over the full spectrum hemp oil they use in the product.  

Containing supporting ingredients such as arnica oil and organic menthol crystals, this formula is custom built to sooth aching muscles and joints. It has a delightful scent, aided by natural ingredients such as ginger, lavender, calendula and wintergreen. 

Strength: About 140mg/oz. full spectrum CBD 


  • Reasonable pricing 
  • Strong supportive ingredients to aid in natural pain relief 
  • Cold pressed CBD oil from only the premium flower part of the plant 
  • Seed to bottle control using superior genetic strains 
  • Kentucky grown and manufactured 
  • All-natural ingredients 
  • Paraben free and vegan friendly 
  • Full spectrum based 



  • Mid-range in terms of strength 



Conclusion: The Right CBD Pain Cream for You 

I hope this article has been a helpful resource for you in your search for where to buy CBD pain creams and salves. I tried to offer a wide range of price ranges, with different supporting ingredients so that you can make a choice that fits your lifestyle.  

I always try to keep my readers informed with the latest research on CBD so they can be knowledgeable consumers. Consider subscribing to my newsletter for occasional updates on the latest news and research in the industry.  

If you decide to make a purchase, be sure to check back here to let other readers know about your experience!