​This review of the best CBD oil for anxiety and depression is designed to give you some background information as well as guidance on the best CBD supplements for their mood-boosting properties.

​Top CBD Brands for Anxiety & Depression




Our #1 Rated

​CBD Pure

​CBD Pure is one of the most established and well respected brands in the CBD space. 

They focus on tinctures and capsules.

Best Edibles

​Hemp Bombs Gummies

​If you like your CBD in the form of a tasty treat then try these Gummies.

They are one of the stronger edibles on the market and taste great. 

Best Vape Oil

Hemp Bombs

So you prefer to vape your cbd oil?  

​Hemp Bombs make a great range of CBD E-liquid with some of the strongest and highest quality options on the market. 

Extreme Stength

​EveryDay Optimal 10,000mg

This is literally the strongest CBD product on the market right now - ​containing a whopping 10,000mg of CBD.

Only experienced users should try this and only if you cannot get relief from a weaker tincture.  

What Does the Research Say?

It is important to note that the Food and Drug Administration has not approved the use of CBD oil for any medical conditions. The FDA approves drugs from pharmaceutical companies on a case by case basis, such as the CBD based drug Epidiolex® recently approved to treat certain kinds of rare childhood epilepsy. But that does not mean that no research demonstrates the mood-boosting properties of cannabidiol.


Of the two, the link between CBD and depression is less well studied. Research that has been conducted on animals as well as the link between the endocannabinoid system (ECS) and the mood state of happiness have shown some promise. Still, major research on CBD and depression in humans is still lacking.

The good news is that the interaction between cannabidiol and the 5-HT1A neuro-receptor, known to be involved in mood and already the target of several pharmaceutical drugs for depression, has been demonstrated. More research on cannabidiol and human depression is likely to be forthcoming in the next few years.



On the other hand, the interaction of the ECS and anxiety has been the subject of a great deal of research. Specifically, CBD has shown some positive effect in several specific types of anxiety in humans, including:

  • Social anxiety
  • Substance Abuse
  • Panic Disorder
  • PTSD
  • Obsessive Compulsive Disorder


Talk with Your Doctor

Both depression and anxiety can be severe enough to become a serious mental health crisis. It is important to understand that although CBD may help some people alleviate some symptoms from either of these disorders, it is neither a cure-all nor a diagnosis.

Mental disorders can have a variety of causes and are best treated by trained professionals that can help properly diagnose and monitor for signs of progression to prevent a mental health emergency.

In addition, cannabidiol can interact with prescription medications that a person may already be taking to treat their illness.

Luckily, more and more people in the medical profession are open to informed patients’ desires to find natural alternatives that have fewer side effects than many of the drugs currently offered from large pharmaceutical companies. Talk to your doctor to discuss if CBD oil is right for you and to get guidance on dosing for your situation.


CBD Oil for Anxiety and Depression Reviews

When it comes to buying CBD oil for anxiety, it is important to do some research to make sure you are getting a high-quality product. Since CBD oil is currently not a regulated product, there are some companies out there trying to cash in on this growing health niche with products sourced from China and even products that don’t contain any CBD at all!

Luckily, I have researched to find out which companies are offering top-notch products. This review includes a variety of different types of products along with some information on each so that you can decide which will work best for you.



CBD oil tinctures are the most popular way to consume cannabidiol supplements. They come in a small bottle that has an eyedropper built into the lid. To take this type of CBD, you just fill the dropper and place the recommended dosage under the tongue and hold it there for about 60 seconds.

This way of taking CBD oil is called sublingual dosing. It absorbs the CBD directly into your system while bypassing digestion. It acts quickly, usually within 5 minutes.

On the other hand, you can use these types of drops by adding them to food or drinks. It can take a little longer, as long as 30 minutes, to feel the effects. However, many people report the effect is subtler and lasts longer when taken this way.

When it comes to tinctures, there are a few great selections, but my top pick is from CBDPure. Here’s why:



  • Full spectrum CBD oil – Contains the complete cannabinoid profile
  • Minimal processing for a terpene and flavonoid-rich oil
  • 90 day satisfaction guarantee – one of the best in the industry
  • Transparent third-party lab testing
  • Sourced from organic hemp grown in Colorado
  • Reasonably priced



  • Only one flavor (hemp) which some will find off putting
  • Narrow product line – focused on oil tinctures and capsules


Featured Products:

CBDPure Hemp Oil 300 – If you decide to give their oil tinctures a try, I would recommend going for the 300mg bottle. Sometimes it can take some time to start to feel the effects of CBD oil, particularly if you have never tried cannabinoids before. This gives you a full month supply, with plenty of time to take advantage of the 90-day money back guarantee if it does not work out for you.

CBDPure Softgels 750 – Some people prefer the convenience of taking a pill for their daily supplement. This ensures precise dosing of 25mg of full spectrum CBD oil every time. Note that if you are new to using CBD for depression or anxiety, this may be a higher dose than you need to start.


Cannabidiol Life

You may have heard of the “Entourage Effect.” This refers to the theory that the 100 or so compounds found in hemp may actually have stronger therapeutic effects when they are taken together. That is why so called “full spectrum” oils sometimes cost a bit more than those based on CBD isolates.

Cannabidiol Life uses a cold press with low pressure and temperature to extract a rich full spectrum oil. This process is time consuming, accounting for a slightly higher price than some competitors.

Here are a few more details to know about Cannabidiol Life:


  • Several flavors available in their CBD oil line
  • Transparent third party testing for each product
  • Full spectrum blends sourced from organic hemp
  • In house manufacturing in Denver, CO
  • Excellent commitment to ingredient selection to include targeted CBD oil blends
  • One of the industry leaders in CBD outreach, advocacy and education



  • A bit more expensive than some competitors, but the quality is there


Featured Products:

Full Spectrum CBD Oil 750mg – Offering a considerable value over their smaller bottle, if you are looking to try their basic blend, this is what I would recommend. The carrier oil is organic MCT coconut oil, a food supplement with its own list of health benefits.

CBG oil – Cannabidiol Life is one of the few reputable companies offering CBD oil. This tincture is made from one of the other cannabinoids found in cannabis: Cannabigerol. Although not as well researched as CBD and THC, this non-psychoactive compound has been identified as a potential therapeutic target for mood disorders such as depression

Hemp Bombs

When it comes to the full range of CBD products, flavors, and the latest and greatest in new ways to try CBD oil,  Hemp Bombs is the place to go.

Many of the products at Hemp Bombs are made from a CBD isolate. For some people, this is more ideal than a full spectrum product because these products don’t contain any THC at all. It also allows for an extremely consistent product in terms of precise CBD dosing.

A bit more about Hemp Bombs:


  • Huge selection of product types and flavors
  • Highly concentrated products available for those with CBD experience
  • Wide line of vape products, preferred by some for anxiety
  • Manufactured in house and sourced from organic hemp from Europe
  • Veteran discount program with a significant price break
  • Outstanding customer service



  • Some products, such as their gummy line, are a little pricier than competitors


Featured Products:

CBD Vape-Oil and Gear – Among the many products to choose from at Hemp Bombs their huge selection of vape products is one that I wanted to make sure you knew about.

A lot of people seem to prefer vaping. This relaxing way to enjoy the benefits is fast acting, discrete, and downright pleasurable.

New to vaping? Hemp Bombs has everything you need to get started.

60 Count CBD Capsules – These 15mg capsules are made with their CBD isolate so they contain no THC. They also include some natural ingredients that boost their anxiety and stress relieving properties including L-Theanine (a natural ingredient from tea), GABA, Magnolia Bark, Scutellaria, and Passiflora. The price break over the 30 count is a considerable savings and a great value.



When it comes to finding the best bang for you buck, it can be hard to find a real full spectrum CBD oil. The big exception to this can be found at CBDistillery. These Colorado natives have made it their mission to make high quality cannabidiol affordable and accessible.


  • Fantastic prices, particularly for larger quantities of full spectrum hemp oil
  • Solid selection of product lines including oils, capsules, and islolates
  • Transparent third party lab testing on their website
  • Excellent reputation for customer service
  • A wide range of specialty isolates for those into the terpene side of CBD
  • Sourced from pesticide free and non-GMO hemp
  • Both full spectrum and THC free CBD oil available
  • Discount program available for veterans, EMTs and police


  • Only natural flavor is available in their hemp oil line


Featured Products:

CBD Vape Cartridge with 200mg Variety Pack – Many folks that are experienced with using CBD for depression or anxiety really like the “on demand” nature of vaping. However, the technology and products can be a little intimidating to the newcomer. This is an excellent value for a starter kit that comes with all the gear you need plus four tasty flavors of CBD infused vape liquid.

1000mg 30ml Full Spectrum CBD Tincture – If you are searching for a deep discount on a full spectrum CBD oil with third party labs that show just how good it really is, then check this deal out. They also have THC free options for those looking for an isolate oil.


Koi Naturals

Based in Norwalk, CA, Koi CBD does all of their hemp sourcing and manufacturing in the USA. They have invested quite a bit in developing unique flavor profiles for their full spectrum products, making them a popular source for vapes and edibles.

Because they use supercritical CO2 extraction, they are able to provide a THC free product that still has all of the other natural terpenes and full spectrum cannabinoids in their products. This process is a bit expensive, accounting for the slightly higher prices of some of their premium products.

Some things you should know about Koi CBD:


  • Colorado sourced hemp from a single grower
  • Supercritical CO2 extraction methods
  • Fantastic focus on natural flavorings with a full line of oils, vapes, and gummies
  • 25% discount for veterans
  • Transparent third party testing on the website



  • The pricing is fair, but a little more than some discount brands


Featured Products:

CBD Gummies – If you are looking to give CBD edibles a try, then I highly recommend these gummies. First, the flavors are really there. They went to the effort to craft distinct tropical flavors made with natural ingredients: Lime, acai pomegranate and tangerine. Plus, they have sours available as well! Each gummy is infused with 10mg of full spectrum CBD oil.

Koi Vape Juice – Again, it’s all about the flavors. When it comes to CBD vaping, Koi has really outdone themselves with really unique custom flavor blends that you just can’t find anywhere else. These delicious juices can also be used as sublingual tinctures.



When it comes to finding a CBD product that will help you with your depression or anxiety, I hope this article gave you want you came for.

I wanted to make sure you had some resources about the benefits of CBD oil and the current state of the research. And, I wanted to make sure you had a great variety of the best of the best to choose from, all from reputable companies with outstanding reputations in the industry.

Make sure to come back and leave a comment if you found one or more of the products reviewed here to be helpful. You just might help other readers find what will work for them!